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Publication

Zinc activates neutrophils' oxidative burst

Title
Zinc activates neutrophils' oxidative burst
Type
Article in International Scientific Journal
Year
2010
Authors
Marisa Freitas
(Author)
Other
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Graca Porto
(Author)
ICBAS
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Eduarda Fernandes
(Author)
FFUP
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Journal
Title: BiometalsImported from Authenticus Search for Journal Publications
Vol. 23 No. 1
Pages: 31-41
ISSN: 0966-0844
Publisher: Springer Nature
Scientific classification
FOS: Natural sciences > Biological sciences
Other information
Authenticus ID: P-003-98E
Abstract (EN): Zinc has been shown to disturb the innate host defense response by interfering in the activation of neutrophils and subsequent oxidative burst, although the exact role of this metal, either as an activator or inhibitor, remains a matter of controversy among research groups. These apparent discrepancies may be due to experimental settings, through modification of zinc availability to neutrophils, or to inaccurate detections of reactive species. Thus, the main objective of the present study was to provide clarification on the role of zinc on the activation of human neutrophils and the subsequent oxidative burst. For that purpose, different detection methods and incubation media were used. The obtained results showed that phosphate buffers (PBS and HBSS) complex with zinc and interfere with the results obtained with this metal. By using Tris-G, it was clearly demonstrated that zinc, at low concentrations (5-12.5 mu M), activates NADPH oxidase, mainly via protein kinase C, leading to the formation of superoxide radical (O(2) (aEuro cent a')). Higher concentrations of zinc results on a rapid dismutation of O(2) (aEuro cent a') to oxygen and hydrogen peroxide, which in turn is used by myeloperoxidase to generate hypochlorous acid (HOCl).
Language: English
Type (Professor's evaluation): Scientific
Contact: egracas@ff.up.pt
No. of pages: 11
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