Spectroscopic and electrochemical studies of cocaine-opioid interactions

• Type: Article in International Scientific Journal
• Date: 2007

Authors

garrido, jorge m. p. j. (Author) Other; marques, m. paula m. (Author) Other; silva, artur m. s. (Author) Other; macedo, tice r. a. (Author) Other; oliveira-brett, ana m. (Author) Other; borges, fernanda (Author) FFUP

Journal

Title: Analytical and Bioanalytical Chemistry

Vol. 388

Pages: 1799-1808

ISSN: 1618-2642

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 28 Citations

Scopus - 33 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

CORDIS: Physical sciences > Chemistry

Other information

Authenticus ID: P-004-893

DOI: 10.1007/s00216-007-1375-z

Abstract (EN): The drugs of abuse cocaine (C), heroin (H), and morphine (M) have been studied to enable understanding of the occurrence of cocaine-opioid interactions at a molecular level. Electrochemical, Raman, and NMR studies of the free drugs and their mixtures were used to study drug-drug interactions. The results were analyzed using data obtained from quantum-mechanical calculations. For the cocaine-morphine mixture (C-MH), formation of a binary complex was detected; this involved the 3-phenolic group and the heterocyclic oxygen of morphine and the carbonyl oxygen and the methyl protons of cocaine's methyl ester group. NMR studies conducted simultaneously also revealed C-MH binding geometry consistent with theoretical predictions and with electrochemical and vibrational spectroscopy results. These results provide evidence for the occurrence of a cocaine-morphine interaction, both in the solid state and in solution, particularly for the hydrochloride form. A slight interaction, in solution, was also detected by NMR for the cocaine-heroin mixture.

Language: English

Type (Professor's evaluation): Scientific