Voltammetric oxidation of drugs of abuse - II. Codeine and metabolites

• Type: Article in International Scientific Journal
• Date: 2004

Authors

Garrido, Jorge M P J (Author) Other; Delerue-Matos, C. M Delerue (Author) Other; Borges, Fernanda Fernanda M (Author) FFUP; Macedo, Tice Reis A (Author) Other; Oliveira-Brett, A. M. (Author) Other

Journal

Title: Electroanalysis

Vol. 16

Pages: 1427-1433

ISSN: 1040-0397

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 38 Citations

Scopus - 40 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

CORDIS: Physical sciences > Chemistry

Other information

Authenticus ID: P-000-8NR

DOI: 10.1002/elan.200302967

Abstract (EN): The oxidation of codeine on glassy carbon electrodes has been studied in detail using differential pulse voltammetry. The results obtained using a glassy carbon electrode clearly show a much more complex oxidation mechanism than that previously reported when platinum and gold electrodes were used. To clarify the codeine oxidative profile, several metabolites and analogues of this alkaloid, codeine N-oxide, norcodeme, dihydrocodeine, acetylcodeine and 6-chlorodesoxycodeine, were synthesized and studied. It was deduced that the anodic waves observed in codeine oxidation are related to the presence of methoxy, hydroxy and tertiary amine groups. Due to the similarity of potentials at which these oxidative processes take place, at some pHs an overlap of peaks occurs and only one anodic wave is observed.

Language: English

Type (Professor's evaluation): Scientific