New ionophores for vitamin B1 and vitamin B6 potentiometric sensors for multivitaminic control

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Ana Rita Pires (Author) Other; Alberto N Araujo (Author) FFUP; Conceicao C B S M Montenegro (Author) FFUP; Petr Chocholous (Author) Other; Petr Solich (Author) Other

Journal

Title: Journal of Pharmaceutical and Biomedical Analysis

Vol. 46 No. 4

Pages: 683-691

ISSN: 0731-7085

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 10 Citations

ISI Web of Science

Scopus - 11 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

CORDIS: Health sciences

Other information

Authenticus ID: P-004-0WQ

DOI: 10.1016/j.jpba.2007.12.003

Resumo (PT): The construction, evaluation and analytical application of potentiometric sensors sensitive to vitamin B1 and vitamin B6 are reported. The solid contact electrodes were produced using β-cyclodextrins as ionophores in a carboxylated poly(vinyl chloride) support matrix. Near Nernstian slopes (mV/decade) of 51.7 ± 0.8, 60.6 ± 0.6 and 61.1 ± 1.4, within the intervals (M) of 1.0 × 10−4 to 1.0 × 10−1, 5.8 × 10−5 to 1.0 × 10−1 and 4.3 × 10−5 to 1.0 × 10−1 were obtained, for thiamine and pyridoxine I and II prepared membranes, respectively. A pH operational range of 6.5–8.5 for thiamine and 2–4.5 for pyridoxine electrodes was found. Assessment of selectivity coefficients toward a large number of inorganic cations and organic cations usually present in multivitamin formulations revealed good performance. Analysis of vitamins B1 and B6 in complex multivitamin drugs was achieved with recoveries within the intervals of 95.1–99.6% for thiamine and 95.1–102% for pyridoxine. Furthermore, the results enabled by the proposed procedure revealed good agreement with those provided by HPLC. <br> <br> Keywords: Cyclodextrins; Thiamine; Pyridoxine; Multivitamin formulations; Ion-selective electrodes <br> <a target="_blank" href="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TGX-4R9JTTS-4&_user=2460038&_coverDate=03%2F13%2F2008&_rdoc=11&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235266%232008%23999539995%23680164%23FLA%23display%23Volume)&_cdi=5266&_sort=d&_docanchor=&_ct=29&_acct=C000057398&_version=1&_urlVersion=0&_userid=2460038&md5=db5a39005ea5445872fd9c59e078c7a7"> Texto integral</a> <br> <br>

Abstract (EN): The construction, evaluation and analytical application of potentiometric sensors sensitive to vitamin B1 and vitamin B6 are reported. The solid contact electrodes were produced using beta-cyclodextrins as ionophores in a carboxylated poly(vinyl chloride) support matrix. Near Nernstian slopes (mV/decade) of 51.7 +/- 0.8, 60.6 +/- 0.6 and 61.1 +/- 1.4, within the intervals (M) of 1.0 x 10(-4) to 1.0 x 10(-1), 5.8 x 10(-5) to 1.0 x 10(-1) and 4.3 x 10(-5) to 1.0 x 10(-1) were obtained, for thiamine and pyridoxine I and II prepared membranes, respectively. A pH operational range of 6.5-8.5 for thiamine and 2-4.5 for pyridoxine electrodes was found. Assessment of selectivity coefficients toward a large number of inorganic cations and organic cations usually present in multivitamin formulations revealed good performance. Analysis of vitamins B1 and B6 in complex multivitamin drugs was achieved with recoveries within the intervals of 95.1-99.6% for thiamine and 95.1-102% for pyridoxine. Furthermore, the results enabled by the proposed procedure revealed good agreement with those provided by HPLC.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9