SEQUENTIAL INJECTION ANALYSIS SYSTEM WITH SPECTROPHOTOMETRIC DETECTION FOR DETERMINATION OF NORFLOXACIN AND CIPROFLOXACIN IN PHARMACEUTICAL FORMULATIONS

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Jose Luiz Rufino (Author) Other; Helena Redigolo Pezza (Author) Other; Leonardo Pezza (Author) Other; Paula C A G Pinto (Author) FFUP; Lucia L M F S Saraiva (Author) FFUP; Jose L F C Lima (Author) FFUP

Journal

Title: Quimica Nova

Vol. 34 No. 3

Pages: 256-261

ISSN: 0100-4042

Publisher: Sociedade Brasileira de Quimica

Indexing

ISI Web of Knowledge - 3 Citations

ISI Web of Science

Scopus - 5 Citations

Scientific classification

CORDIS: Health sciences > Pharmacological sciences

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-002-XPK

DOI: 10.1590/s0100-40422011000200016

Resumo (PT): This work proposes a sequential injection analysis (SIA) system for the spectrophotometric determination of norfloxacin (NOR) and ciprofloxacin (CIP) in pharmaceutical formulations. The methodology was based on the reaction of these drugs with p-(dimethylamino)cinnamaldehyde in micellar medium, producing orange colored products (λmax = 495 nm). Beer´s law was obeyed in the concentration range from 2.75x10-5 to 3.44x10–4 mol L-1 and 3.26x10-5 to 3.54x10–4 mol L-1 for NOR and CIP, respectively and sampling rate was 25 h-1. Commercial samples were analyzed and results obtained through the proposed method were in good agreement with those obtained using the reference procedure for a 95% confidence level. <br> <br> Keywords: sequential injection analysis; spectrophotometry; pharmaceutical formulations <br> <a target="_blank" href="http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0100-40422011000200016&lng=en&nrm=iso&tlng=en "> Texto integral </a> <br> <br>

Abstract (EN): This work proposes a sequential injection analysis (SIA) system for the spectrophotometric determination of norfloxacin (NOR) and ciprofloxacin (CIP) in pharmaceutical formulations. The methodology was based on the reaction of these drugs with p-(dimethylamino) cinnamaldehyde in micellar medium, producing orange colored products (lambda(max) = 495 nm). Beer's law was obeyed in the concentration range from 2.75x10(-5) to 3.44x10(-4) mol L(-1) and 3.26x10(-5) to 3.54x10(-4) mol L(-1) for NOR and CIP, respectively and sampling rate was 25 h(-1). Commercial samples were analyzed and results obtained through the proposed method were in good agreement with those obtained using the reference procedure for a 95% confidence level.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6