Diazepam Fluorimetric Monitoring Upon Photo-Degradation in an Automatic Miniaturized Flow System

• Type: Article in International Scientific Journal
• Date: 2010

Authors

David S M Ribeiro (Author) Other; Joao A V Prior (Author) FFUP; Joao L M Santos (Author) FFUP; Jose L F C Lima (Author) FFUP

Journal

Title: Journal of Fluorescence

Vol. 20

Pages: 915-922

ISSN: 1053-0509

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 4 Citations

ISI Web of Science

Scopus - 4 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

CORDIS: Health sciences

Other information

Authenticus ID: P-003-5AX

DOI: 10.1007/s10895-010-0637-x

Resumo (PT): The present work describes the fully integration in line of a photo-degradation unit, comprising a low pressure UV lamp, in a Multipumping Flow System (MPFS), for the fluorimetric chemical control of commercially available pharmaceutical formulations containing diazepam. The utilization of an organized micellar medium provided enhanced fluorescence emission. The results allowed to obtain a linear working range for diazepam concentrations of up to 40 mg L−1 (r = 0.9998) and the detection limit was about 0.97 mg L−1. The results obtained by the miniaturized and automatic flow system were in agreement with those furnished by the reference procedure, with relative deviations comprised between −2.09% and 2.13%. <br> <br> Keywords Miniaturized - Flow analysis - Multipumping - Diazepam - Photo-degradation - Spectrofluorimetry <br> <a target="_blank" href="http://www.springerlink.com/content/6513748p236m1u26/"> Texto integral <br> <br>

Abstract (EN): The present work describes the fully integration in line of a photo-degradation unit, comprising a low pressure UV lamp, in a Multipumping Flow System (MPFS), for the fluorimetric chemical control of commercially available pharmaceutical formulations containing diazepam. The utilization of an organized micellar medium provided enhanced fluorescence emission. The results allowed to obtain a linear working range for diazepam concentrations of up to 40 mg L(-1) (r = 0.9998) and the detection limit was about 0.97 mg L(-1). The results obtained by the miniaturized and automatic flow system were in agreement with those furnished by the reference procedure, with relative deviations comprised between -2.09% and 2.13%.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8