Pharmacogenetic Approaches in Personalized Medicine for Postoperative Pain Management

• Type: Another Publication in an International Scientific Journal
• Date: 2024

Authors

do Couto, MLF (Author) Other; Fonseca, S (Author) Other; Daniel Pozza (Author) FMUP

Journal

Title: Biomedicines

Vol. 60

Final page: 729

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-010-CHW

DOI: 10.3390/biomedicines12040729

Abstract (EN): Despite technical and pharmacological advancements in recent years, including optimized therapies and personalized medicine, postoperative pain management remains challenging and sometimes undertreated. This review aims to summarize and update how genotype-guided therapeutics within personalized medicine can enhance postoperative pain management. Several studies in the area have demonstrated that genotype-guided therapy has the ability to lower opioid consumption and improve postoperative pain. Gene mutations, primarily OPRM1, CYP2D6, CYP2C9, COMT and ABCB1, have been shown to exert nuanced influences on analgesic response and related pharmacological outcomes. This review underscores the integration of pharmacogenetic-guided personalized medicine into perioperative care, particularly when there is uncertainty regarding opioid prescriptions. This approach leads to superior outcomes in terms of postoperative pain relief and reduced morbidity for numerous patients.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 20