Saponin-based natural nanoemulsions as alpha-tocopherol delivery systems for dermal applications

• Type: Article in International Scientific Journal
• Date: 2023

Authors

Schreiner, TB (Author) Other; Santamaria Echart, A (Author) Other; Colucci, G (Author) Other; Plasencia, P (Author) Other; Costa, PS (Author) Other; Madalena M. Dias (Author) FEUP; Pinho, SP (Author) Other; Barreiro, MF (Author) Other

Journal

Title: Journal of Molecular Liquids

Vol. 391

ISSN: 0167-7322

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Associated Projects

LA LSRE-LCM - Financiamento Plurianual 2020-2023 para a Unidade LA LSRE-LCM Laboratório de Processos de Separação e Reacção - Laboratório de Catálise e Materiais

Other information

Authenticus ID: P-00Z-8C8

DOI: 10.1016/j.molliq.2023.123371

Abstract (EN): Nanoemulsions can be produced using simple methods and compounds from natural sources. They can increase water dispersibility and bioavailability and optimise active ingredient dispersion in particular skin layers. Lipophilic compounds of the vitamin E family (tocopherols and tocotrienols) are well-known for their high antioxidant activity and capacity to protect the skin from oxidative stress. In this context, oil-in-water (o/w) nanoemulsions with and without alpha-tocopherol (Vitamin E, VE) were formulated with two emulsifier alternatives, Quillaja saponin (QS), and a combination of QS with Tribulus terrestris (QSTT) (50/50, w/w). The emulsions were evaluated concerning stability, microstructure, droplet size, colour attributes, encapsulation efficiency, UV photostability, antioxidant activity, and in vitro permeation studies to assess the delivery potential. Results showed highly stable systems, with round-shape droplets of 80-121 nm size. QS and QSTT samples' colours were close to white and light brownish, respectively. The topical nano cream had the capacity to entrap VE, producing a protective effect from UV degradation, and very significant antioxidant activity, with IC50 values around 0.01 %wt. The skin permeation profiles showed the efficiency of the formulations in the delivery of VE, with permeabilities between 64 and 74 mu g/cm2, while the control sample showed no VE permeation.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12