The MLL recombinome of acute leukemias in 2013

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Meyer, C (Author) Other; Hofmann, J (Author) Other; Burmeister, T (Author) Other; Groger, D (Author) Other; Park, TS (Author) Other; Emerenciano, M (Author) Other; de Oliveira, MP (Author) Other; Renneville, A (Author) Other; Villarese, P (Author) Other; Macintyre, E (Author) Other; Cave, H (Author) Other; Clappier, E (Author) Other; Mass Malo, K (Author) Other; Zuna, J (Author) Other; Trka, J (Author) Other; De Braekeleer, E (Author) Other; De Braekeleer, M (Author) Other; Oh, SH (Author) Other; Tsaur, G (Author) Other; Fechina, L (Author) Other; van der Velden, VHJ (Author) Other; van Dongen, JJM (Author) Other; Delabesse, E (Author) Other; Binato, R (Author) Other; Silva, MLM (Author) Other; Kustanovich, A (Author) Other; Aleinikova, O (Author) Other; Harris, MH (Author) Other; Lund Aho, T (Author) Other; Juvonen, V (Author) Other; Heidenreich, O (Author) Other; Vormoor, J (Author) Other; Choi, WWL (Author) Other; Jarosova, M (Author) Other; Kolenova, A (Author) Other; Bueno, C (Author) Other; Menendez, P (Author) Other; Wehner, S (Author) Other; Eckert, C (Author) Other; Talmant, P (Author) Other; Tondeur, S (Author) Other; Lippert, E (Author) Other; Launay, E (Author) Other; Henry, C (Author) Other; Ballerini, P (Author) Other; Lapillone, H (Author) Other; Callanan, MB (Author) Other; Cayuela, JM (Author) Other; Herbaux, C (Author) Other; Cazzaniga, G (Author) Other; Kakadiya, PM (Author) Other; Bohlander, S (Author) Other; Ahlmann, M (Author) Other; Choi, JR (Author) Other; Gameiro, P (Author) Other; Lee, DS (Author) Other; Krauter, J (Author) Other; Cornillet Lefebvre, P (Author) Other; Kronnie, GT (Author) Other; Schafer, BW (Author) Other; Kubetzko, S (Author) Other; Alonso, CN (Author) Other; Stadt, UZ (Author) Other; Sutton, R (Author) Other; Venn, NC (Author) Other; Izraeli, S (Author) Other; Trakhtenbrot, L (Author) Other; Madsen, HO (Author) Other; Archer, P (Author) Other; Hancock, J (Author) Other; cerveira, n (Author) Other; Manuel R Teixeira (Author) ICBAS; Lo Nigro, L (Author) Other; Moricke, A (Author) Other; Stanulla, M (Author) Other; Schrappe, M (Author) Other; Sedek, L (Author) Other; Szczepanski, T (Author) Other; Zwaan, CM (Author) Other; Coenen, EA (Author) Other; van den Heuvel Eibrink, MM (Author) Other; Strehl, S (Author) Other; Dworzak, M (Author) Other; Panzer Grumayer, R (Author) Other; Dingermann, T (Author) Other; Klingebiel, T (Author) Other; Marschalek, R (Author) Other

Journal

Title: Leukemia

Vol. 27

Pages: 2165-2176

ISSN: 0887-6924

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 309 Citations

Scopus - 327 Citations

Other information

Authenticus ID: P-008-GEP

DOI: 10.1038/leu.2013.135

Abstract (EN): Chromosomal rearrangements of the human MLL (mixed lineage leukemia) gene are associated with high-risk infant, pediatric, adult and therapy-induced acute leukemias. We used long-distance inverse-polymerase chain reaction to characterize the chromosomal rearrangement of individual acute leukemia patients. We present data of the molecular characterization of 1590 MLL-rearranged biopsy samples obtained from acute leukemia patients. The precise localization of genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs) were determined and novel TPGs identified. All patients were classified according to their gender (852 females and 745 males), age at diagnosis (558 infant, 416 pediatric and 616 adult leukemia patients) and other clinical criteria. Combined data of our study and recently published data revealed a total of 121 different MLL rearrangements, of which 79 TPGs are now characterized at the molecular level. However, only seven rearrangements seem to be predominantly associated with illegitimate recombinations of the MLL gene (similar to 90%): AFF1/AF4, MLLT3/AF9, MLLT1/ENL, MLLT10/AF10, ELL, partial tandem duplications (MLL PTDs) and MLLT4/AF6, respectively. The MLL breakpoint distributions for all clinical relevant subtypes (gender, disease type, age at diagnosis, reciprocal, complex and therapy-induced translocations) are presented. Finally, we present the extending network of reciprocal MLL fusions deriving from complex rearrangements.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12