GLP-1 Increases Circulating Leptin Levels in Truncal Vagotomized Rats

• Type: Article in International Scientific Journal
• Date: 2023

Authors

Morais, T (Author) Other; Pereira, SS (Author) ICBAS; Andrade, S (Author) Other; Neves, D (Author) Other; Guimaraes, M (Author) Other; Nora, M (Author) Other; Carreira, MC (Author) Other; Casanueva, FF (Author) Other; Monteiro, M (Author) ICBAS

Journal

Title: Biomedicines

Vol. 11

Final page: 1322

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00Y-B5R

DOI: 10.3390/biomedicines11051322

Abstract (EN): GLP-1 is a gastro-intestinal hormone acting within the gut/brain axis for energy balance regulation. We aimed to evaluate the role of the vagus nerve in whole-body energy homeostasis and in mediating GLP-1 effects. For this, rats submitted to truncal vagotomy and sham-operated controls underwent a comprehensive evaluation, including eating behavior, body weight, percentage of white (WAT) and brown adipose tissue (BAT), resting energy expenditure (REE) and acute response to GLP-1. Truncal vagotomized rats had significantly lower food intake, body weight, body weight gain, WAT and BAT, with a higher BAT/WAT ratio, but no significant difference in REE when compared to controls. Vagotomized rats also had significantly higher fasting ghrelin and lower glucose and insulin levels. After GLP-1 administration, vagotomized rats depicted a blunted anorexigenic response and higher plasma leptin levels, as compared to controls. However, in vitro stimulation of VAT explants with GLP-1 resulted in no significant changes in leptin secretion. In conclusion, the vagus nerve influences whole-body energy homeostasis by modifying food intake, body weight and body composition and by mediating the GLP-1 anorectic response. The higher leptin levels in response to acute GLP-1 administration observed after truncal vagotomy suggest the existence of a putative GLP-1-leptin axis that relies on the integrity of gut-brain vagal pathway.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13