Microemulsion and Microemulsion-Based Gels for Topical Antifungal Therapy with Phytochemicals

• Type: Another Publication in an International Scientific Journal
• Date: 2016

Authors

Boonme, P (Author) Other; Kaewbanjong, J (Author) Other; Amnuaikit, T (Author) Other; Andreani, T (Author) Other; Silva, AM (Author) Other; Souto, EB (Author) Other

Journal

Title: Current Pharmaceutical Design

Vol. 22

Pages: 4257-4263

ISSN: 1381-6128

Publisher: Bentham Science

Indexing

ISI Web of Knowledge - 22 Citations

Scopus - 23 Citations

Other information

Authenticus ID: P-00K-VGH

DOI: 10.2174/1381612822666160603015436

Abstract (EN): Background: Skin fungal infections are regular injuries suffered by people living in tropical areas. Most common pathogens are Trichophyton, Microsporum and Epidermophyton which can cause skin lesions in many parts of body. Topical antifungal phytochemicals are commonly used to avoid systemic adverse events and are more convenient for patient application than those administered by other routes. However, the effectiveness of topical treatments in eradicating fungal infection is more limited since the stratum corneum acts as the skin barrier, resulting in long treatment duration and low patient's compliance. Methods: The goal of this work is to identify optimized drug delivery systems to improve topic clinical efficacy. Microemulsions i.e. liquid dispersions of oil and water stabilized with an interfacial film of surfactant are well known drug delivery systems. Results: A thickening agent may be included to form microemulsion-based gels to increase skin adhesion. Microemulsions and microemulsion-based gels can be loaded with several hydrophilic and lipophilic drugs because they are composed of both water and oil phases. Conclusion: Microemulsions and microemulsion-based gels can also be used for the delivery of many drugs including antifungal drugs through stratum corneum due to their capacity to act as skin penetration enhancement. In addition to a comprehensive review of microemulsion and microemulsion-based gels as suitable carriers for skin delivery of various antifungal drugs, this review also aims to discuss the delivery of antifungal phytochemicals.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7