Sequential reactions from catalytic hydroformylation toward the synthesis of amino compounds

• Type: Article in International Scientific Journal
• Date: 2017

Authors

Almeida, AR (Author) Other; Carrilho, RMB (Author) Other; Peixoto, AF (Author) FCUP; Abreu, AR (Author) Other; Silva, A (Author) Other; Pereira, MM (Author) Other

Journal

Title: Tetrahedron

Vol. 73

Pages: 2389-2395

ISSN: 0040-4020

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 7 Citations

Other information

Authenticus ID: P-00M-QNS

DOI: 10.1016/j.tet.2017.03.023

Abstract (EN): Different families of new amino compounds were efficiently synthesized, through optimized sequential processes, involving rhodium catalyzed hydroformylation as the key step. The selection of appropriate hydroformylation catalytic systems and reaction conditions allowed obtaining aldehydes derived from several n-alkyl olefins, cholest-4-ene and 3-vinyl-1H-indole, which were subsequently transformed, in one-pot, in to alpha-amino acids via hydroformylation/Strecker reaction, and in to tertiary amines via hydroaminomethylation, with excellent yields.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7