Diarylpentanoids with antitumor activity: A critical review of structure-activity relationship studies

• Type: Another Publication in an International Scientific Journal
• Date: 2020

Authors

Moreira, J (Author) Other; Lucilia Saraiva (Author) FFUP; Pinto, MM (Author) Other; Honorina Cidade (Author) FFUP

Journal

Title: European Journal of Medicinal Chemistry

Vol. 192

ISSN: 0223-5234

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 11 Citations

Scopus - 13 Citations

Other information

Authenticus ID: P-00R-VCG

DOI: 10.1016/j.ejmech.2020.112177

Abstract (EN): Diarypentanoids are commonly considered as monocarbonyl analogues of curcumin. Since the discovery of this compound in 1962, twenty one diarylpentanoids have been isolated and almost 600 synthetic analogues with antitumor activity have been synthesized. This review reports the exploitation of diarylpentanoids to develop curcumin analogues with improved antitumor activity over the last two decades. The mechanism of action and structure-activity relationship (SAR) studies are also highlighted. More importantly, structural features for the antitumor activity that may guide the design of new and more effective diarylpentanoids are also proposed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 26