Antifouling Marine Coatings with a Potentially Safer and Sustainable Synthetic Polyphenolic Derivative

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Neves, AR (Author) Other; Luciana Gomes (Author) FEUP; Faria, SI (Author) Other; Sousa, J (Author) Other; Ruivo, R (Author) Other; Pascoa, I (Author) Other; Pinto, M (Author) Other; Emilia Sousa (Author) FFUP; Santos, MM (Author) FCUP; Silva, ER (Author) Other; Marta Correia da Silva (Author) FFUP; Filipe Mergulhão (Author) FEUP

Journal

Title: Marine Drugs

Vol. 12

Final page: 507

ISSN: 1660-3397

Publisher: MDPI

Indexing

ISI Web of Knowledge - 6 Citations

Scopus - 5 Citations

Associated Projects

ALiCE - ALiCE - Laboratório Associado em Engenharia Química

LEPABE - Financiamento Plurianual 2020-2023 da Unidade de I&D LEPABE - Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia

Healthy Waters - Healthy Waters - Identification, Elimination, Social Awareness and Education of Water Chemical and Biological Micropollutants with Health and Environmental Implications

Other information

Authenticus ID: P-00X-0SD

DOI: 10.3390/md20080507

Abstract (EN): The development of harmless substances to replace biocide-based coatings used to prevent or manage marine biofouling and its unwanted consequences is urgent. The formation of biofilms on submerged marine surfaces is one of the first steps in the marine biofouling process, which facilitates the further settlement of macrofoulers. Anti-biofilm properties of a synthetic polyphenolic compound, with previously described anti-settlement activity against macrofoulers, were explored in this work. In solution this new compound was able to prevent biofilm formation and reduce a pre-formed biofilm produced by the marine bacterium, Pseudoalteromonas tunicata. Then, this compound was applied to a marine coating and the formation of P. tunicata biofilms was assessed under hydrodynamic conditions to mimic the marine environment. For this purpose, polyurethane (PU)-based coating formulations containing 1 and 2 wt.% of the compound were prepared based on a prior developed methodology. The most effective formulation in reducing the biofilm cell number, biovolume, and thickness was the PU-based coating containing an aziridine-based crosslinker and 2 wt.% of the compound. To assess the marine ecotoxicity impact of this compound, its potential to disrupt endocrine processes was evaluated through the modulation of two nuclear receptors (NRs), peroxisome proliferator-activated receptor gamma (PPAR gamma), and pregnane X receptor (PXR). Transcriptional activation of the selected NRs upon exposure to the polyphenolic compound (10 mu M) was not observed, thus highlighting the eco-friendliness towards the addressed NRs of this new dual-acting anti-macro- and anti-microfouling agent towards the addressed NRs.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12