Pathophysiological Mechanisms of Chronic Venous Disease and Implications for Venoactive Drug Therapy

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Mansilha A. (Author) FMUP; Sousa, J (Author) FMUP

Journal

Title: International Journal Of Molecular Sciences

Vol. 19

Final page: 1669

ISSN: 1661-6596

Publisher: MDPI

Indexing

ISI Web of Knowledge - 116 Citations

Scopus - 130 Citations

Other information

Authenticus ID: P-00P-2Q7

DOI: 10.3390/ijms19061669

Abstract (EN): Chronic venous disease (CVD) is a common pathology, with significant physical and psychological impacts for patients and high economic costs for national healthcare systems. Throughout the last decades, several risk factors for this condition have been identified, but only recently, have the roles of inflammation and endothelial dysfunction been properly assessed. Although still incompletely understood, current knowledge of the pathophysiological mechanisms of CVD reveals several potential targets and strategies for therapeutic intervention, some of which are addressable by currently available venoactive drugs. The roles of these drugs in the clinical improvement of venous tone and contractility, reduction of edema and inflammation, as well as in improved microcirculation and venous ulcer healing have been studied extensively, with favorable results reported in the literature. Here, we aim to review these pathophysiological mechanisms and their implications regarding currently available venoactive drug therapies.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 21