Defective upper gastrointestinal function after repair of combined esophageal and duodenal atresia

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Fragoso AC (Author) FMUP; Ortiz, R (Author) Other; Hernandez, F (Author) Other; Olivares, P (Author) Other; Martinez, L (Author) Other; Tovar, JA (Author) Other

Journal

Title: Journal of Pediatric Surgery

Vol. 50

Pages: 531-534

ISSN: 0022-3468

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 7 Citations

Other information

Authenticus ID: P-00A-BMC

DOI: 10.1016/j.jpedsurg.2014.05.029

Abstract (EN): Background: Both esophageal atresia (EA) and duodenal atresia (DA) involve deficient anti-reflux barrier, poor esophageal function and eventually, duodenogastric reflux. This study aims at examining the upper gastrointestinal functional status in a cohort of patients with both EA and DA. Methods: A retrospective survey of patients treated for EA and DA between 1965 and 2012 was conducted. Clinical charts, office visits, imaging, upper gastrointestinal endoscopy and esophageal pH metry/impedance were used to assess the long-term condition of the esophagus, the presence of gastroesophageal reflux disease (GERD) and/or the need for fundoplication. Results: Twenty out of 581 patients treated for EA had associated DA. Ten/twenty children survived; 1 had primary esophageal replacement. With a median follow-up of 9 years, 8/9 had complicated outcomes and 5 still suffered digestive ailments: 2 GER; 1 eosinophilic esophagitis; 1 nodular gastritis, and 1 wrap herniation. A total of 10 procedures were performed: 8 fundoplications, 1 esophagogastric dissociation and 1 replacement with colon. Discussion: The association of EA with DA involves a poor upper digestive function with high risks of GERD and fundoplication failure. The lifelong synergistic play of esophageal, gastric and duodenal dysfunctions in these patients prompts long-term follow-up, and eventually active treatment.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4