Association between parity and breast cancer among women in north-central Nigeria: An exploratory case-control analysis

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Kana, MA (Author) Other; Ari, M (Author) Other; Solomon, P (Author) Other; Lunet N (Author) FMUP

Journal

Title: Arquivos de Medicina

Vol. 29

Pages: 132-134

ISSN: 0871-3413

Publisher: A E F M U P, Alameda prof. H. Montiero

Indexing

Scopus - 1 Citation

Other information

Authenticus ID: P-00K-TEW

Abstract (EN): BACKGROUND: Many studies conducted over the years have recognized the substantial epidemiologic evidence on the contribution of reproductive factors for the occurrence of breast carcinoma, including parity. However, most studies evaluated relatively homogeneous populations, with a small number of women with high fertility, and the association of very high parity with breast cancer remains poorly understood. Therefore, we addressed this topic in an African population characterized by high fertility rates. METHODS: We conducted a case-control analysis among women that were attending the Taimako breast and cervical cancer-screening centre, which is located in Nasarawa state of North-Central Nigeria. RESULTS: Among cases, 34.5% of the women were 39 years or less. About a quarter had ever used oral contraceptives, nearly half had attained menopause, and nearly two thirds had parity higher than 4 (parity 5-6, 32.1%; parity 7-8, 25.0%, parity ¿9, 7.1%). Compared to women with parity 1-4 the risk of breast cancer tended to be higher among nulliparous women (OR=3.44, 95%CI: 0.68-17.54), though it was lower among those aged ¿45 years (OR=1.43, 95%CI: 0.11-18.22) and higher in participants aged >45 years (OR=12.07, 95%CI: 0.62-233.00). For women with higher parity, the OR estimates were similar for those with parity 5-6 (OR=2.54, 95%CI: 0.80-8.01) and 7-8 (OR=2.65, 95%CI: 0.74-9.48). CONCLUSION: Our results suggest that future increase in incident breast cancer cases in this setting may result from an improvement of screening and diagnostic services, rather than from a dramatic but unlikely reduction in parity.

Language: English

Type (Professor's evaluation): Scientific