Anti-cardiac troponin antibodies in clinical human disease: a systematic review

• Type: Another Publication in an International Scientific Journal
• Date: 2017

Authors

Vilela, EM (Author) Other; Bettencourt Silva, R (Author) Other; Torres da Costa, JT (Author) Other; Barbosa, AR (Author) Other; Silva, MP (Author) Other; Teixeira, M (Author) Other; Primo, J (Author) Other; Ribeiro, VG (Author) Other; José Pedro Nunes (Author) FMUP

Journal

Title: Annals of Translational Medicine

Vol. 5

Pages: 307-307

ISSN: 2305-5839

Publisher: AME Publishing Company

Indexing

ISI Web of Knowledge - 16 Citations

Scopus - 21 Citations

Other information

Authenticus ID: P-00M-ZE3

DOI: 10.21037/atm.2017.07.40

Abstract (EN): Anti-cardiac troponin antibodies have been studied in different types of clinical diseases and in healthy populations. A systematic review of published data on anti-troponin antibodies was carried out (search performed on PubMed, ISI Web of Knowledge and Scopus databases). From title and abstract analysis, thirty-three articles were included that met the pre-specified criteria; after full-text analysis, nine articles were excluded. Most studies assessed anti-troponin I antibodies. The prevalence of anti-cardiac troponin antibodies in healthy individuals ranged from 0.0% to 20.0%. The prevalence of anti-troponin I autoantibodies in dilated cardiomyopathy (DCM) ranged from 7.0% to 22.2%. Other conditions under study were myocardial infarction, ischemic cardiomyopathy (ICM), peripartum cardiomyopathy (PPCM), Chagas disease, Emery-Dreifuss muscular dystrophy (EDMD) and renal transplantation. In the different patient populations studied, anti-cardiac troponin antibodies have been shown to be either positively or negatively associated with prognostic and clinical features. In what concerns a possible value as biomarkers, these assays have not emerged up to the present moment as important aids for practical clinical decisions in cardiac or other types of patients. In what concerns pathophysiology, anti-cardiac troponin autoantibodies may play a role in different diseases. It can be speculated that these antibodies could be involved in perpetuating some degree of cardiac injury after an event, such as myocardial infarction or PPCM.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 16