Whipple disease and central nervous system [Doença de whipple e sistema nervoso central]

• Type: Another Publication in an International Scientific Journal
• Date: 2005

Authors

Pedro Abreu (Author) Other; Elsa Azevedo (Author) FMUP; Lobo, L (Author) Other; Moura, CS (Author) Other; Pontes, C (Author) Other

Journal

Title: Acta Medica Portuguesa

Vol. 18 No. 4

Pages: 199-208

ISSN: 0870-399X

Publisher: Ordem dos Medicos

Indexing

Scopus - 3 Citations

Other information

Authenticus ID: P-007-DMW

Abstract (EN): Whipple disease (WD) is a rare systemic infection caused by the bacteria Tropheryma whipplei. Slowly progressive dementia, supranuclear ophthalmoplegia, headache, myoclonus, hypothalamic dysfunction, oculomasticatory-skeletal myorythmia are characteristic manifestations when WD involves the central nervous system (CNS). Treatment of cerebral WD should be performed with antibiotics that reach the CNS for at the least one-year. We alert for the early diagnosis of WD in patients with exclusively neurological clinical pictures, sometimes with atypical or non-definitive diagnosis, because it is a potential treatable disease.

Language: Portuguese

Type (Professor's evaluation): Scientific