Autoimmunity arising from bystander proliferation of T cells in animmune response model

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Burroughs, N.J. (Author) FCNAUP; Ferreira, M. (Author) Other; Oliveira, Bruno (Author) FCNAUP; Pinto, A.A. (Author) FCNAUP

Journal

Title: Mathematical and Computer Modelling

Vol. 53 No. 7/8

Pages: 1389-1393

ISSN: 0895-7177

Publisher: Pergamon Press - Elsevier

Indexing

ISI Web of Knowledge - 23 Citations

ISI Web of Science

Scopus - 26 Citations

Scientific classification

FOS: Medical and Health sciences > Health sciences

CORDIS: Health sciences

Other information

Authenticus ID: P-002-SGJ

Resumo (PT): We study a mathematical model of immune response by T cells where the regulatory T cells (Treg) inhibit interleukin 2 secretion. The bystander proliferation to an immune response is modelled. We consider an asymmetry reflecting that the difference between the growth and death rates can be higher for the active T cells and Tregs than for the inactive. This asymmetry leads to a better understanding of the bystander proliferation. An exposure to a pathogen results in an increased proliferation rate of the bystander T cells. If the population of the bystander T cells becomes large enough, autoimmunity can arise, eventually after a long transient period. (C) 2010 Elsevier Ltd. All rights reserved.

Abstract (EN): We study a mathematical model of immune response by T cells where the regulatory T cells (Treg) inhibit interleukin 2 secretion. The bystander proliferation to an immune response is modelled. We consider an asymmetry reflecting that the difference between the growth and death rates can be higher for the active T cells and Tregs than for the inactive. This asymmetry leads to a better understanding of the bystander proliferation. An exposure to a pathogen results in an increased proliferation rate of the bystander T cells. If the population of the bystander T cells becomes large enough, autoimmunity can arise, eventually after a long transient period. (C) 2010 Elsevier Ltd. All rights reserved.

Language: English

Type (Professor's evaluation): Scientific

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