A comprehensive review on xanthone derivatives as alpha-glucosidase inhibitors

• Type: Another Publication in an International Scientific Journal
• Date: 2018

Authors

Santos, CMM (Author) Other; Freitas, M (Author) Other; Eduarda Fernandes (Author) FFUP

Journal

Title: European Journal of Medicinal Chemistry

Vol. 157

Pages: 1460-1479

ISSN: 0223-5234

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 6 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00P-KZK

DOI: 10.1016/j.ejmech.2018.07.073

Abstract (EN): alpha-Glucosidase plays an important role in carbohydrate metabolism and is therefore an attractive therapeutic target for the treatment of diabetes, obesity and other related complications. In the last two decades, considerable interest has been given to natural and synthetic xanthone derivatives in this field of research. Herein, a comprehensive review of the literature on xanthones as inhibitors of alpha-glucosidase activity, their mechanism of action, experimental procedures and structure-activity relationships have been reviewed for more than 280 analogs. With this overview we intend to motivate and challenge researchers (e.g. chemistry, biology, pharmaceutical and medicinal areas) for the design of novel xanthones as multipotent drugs and exploit the properties of this class of compounds in the management of diabetic complications.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 20