Levels of urinary biomarkers of exposure and potential genotoxic risks in firefighters risks

• Type: Chapter or Part of a Book
• Date: 2018

Authors

Marta Oliveira (Author) Other; Cristina Delerue Matos (Author) Other; Simone Morais (Author) Other; Klara Slezakova (Author) FEUP; Maria do Carmo Pereira (Author) FEUP; Adília Fernandes (Author) Other; Solange Costa (Author) Other; João Paulo Teixeira (Author) Other

Book

Title: Occupational Safety and Hygiene VI

Pages: 267-271

ISBN: 978-1-138-54203-7

Publisher: Taylor & Francis

Indexing

ISI Web of Science

Scopus

Associated Projects

LEPABE - Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia

Other information

DOI: 10.1201/9781351008884-47

Abstract (EN): This study characterizes the levels of six urinary monohydroxyl-polycyclic aromatic hydrocarbons in Portuguese firefighters directly involved in firefighting activities. Median concentrations of urinary total monohydroxyl-PAHs were predominantly higher in exposed subjects comparatively with non-exposed firefighters (3.12 versus 1.59 μmol/mol creatinine, respectively). Urinary 1-hydroxynaphthalene and 1-hydroxyacenaphthene were the most predominant metabolites (87–90% of total monohydroxyl-PAHs), being followed by 2-hydroxylfluorene (2.4–6.3%), 1-hydroxyphenanthrene (4.1–5.4%), and 1-hydroxypyrene (2.0–2.6%). Firefighters who were directly involved in fire combat activities presented increased percentages of DNA damage (9.85 versus 10.9%; p ≤ 0.01) and oxidative stress (0 versus 2.14% TDNA; p ≤ 0.01) comparatively with non-exposed subjects, thus revealing the impact of fires on the health of exposed firefighters. © 2018 Taylor & Francis Group, London.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5