Celiac disease diagnosis and gluten-free food analytical control

• Type: Another Publication in an International Scientific Journal
• Date: 2010

Authors

Marta Maria P D Pereira da Silva Neves (Author) Other; Maria B Begona Gonzalez Garcia (Author) Other; Hendrikus Petrus A Antonius Nouws (Author) Other; Cristina Delerue Matos (Author) Other; Alice Santos Silva (Author) FFUP; Agustin Costa Garcia (Author) Other

Journal

Title: Analytical and Bioanalytical Chemistry

Vol. 397 No. 7

Pages: 1743-1753

ISSN: 1618-2642

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 20 Citations

Scopus - 24 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-003-50K

DOI: 10.1007/s00216-010-3753-1

Abstract (EN): Celiac disease (CD) is an autoimmune enteropathy, characterized by an inappropriate T-cell-mediated immune response to the ingestion of certain dietary cereal proteins in genetically susceptible individuals. This disorder presents environmental, genetic, and immunological components. CD presents a prevalence of up to 1% in populations of European ancestry, yet a high percentage of cases remain underdiagnosed. The diagnosis and treatment should be made early since untreated disease causes growth retardation and atypical symptoms, like infertility or neurological disorders. The diagnostic criteria for CD, which requires endoscopy with small bowel biopsy, have been changing over the last few decades, especially due to the advent of serological tests with higher sensitivity and specificity. The use of serological markers can be very useful to rule out clinical suspicious cases and also to help monitor the patients, after adherence to a gluten-free diet. Since the current treatment consists of a life-long gluten-free diet, which leads to significant clinical and histological improvement, the standardization of an assay to assess in an unequivocal way gluten in gluten-free foodstuff is of major importance.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11