Tetracycline, oxytetracycline and chlortetracycline determination by flow injection potentiometry

• Type: Article in International Scientific Journal
• Date: 1998

Authors

Couto, CMCM (Author) Other; Lima, JLFC (Author) FFUP; Conceicao, M (Author) FFUP; Montenegro, BSM (Author) Other; Reis, S (Author) FFUP

Journal

Title: Journal of Pharmaceutical and Biomedical Analysis

Vol. 18

Pages: 527-533

ISSN: 0731-7085

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 29 Citations

Scopus - 28 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-001-6NM

DOI: 10.1016/s0731-7085(98)00207-6

Abstract (EN): This paper describes tetracycline (TCH), oxytetracycline (OTCH) and chlortetracycline (CTCH) determination by flow injection potentiometry. In the flow system proposed TC samples are inserted in a carrier solution and converged with a Cu(II) solution of known concentration; the Cu(II) decrease due to its complexation with tetracyclines (TC) was monitored. The detector used was a homogeneous crystalline CuS/Ag2S double membrane tubular electrode with increased sensitivity. The present system allows tetracyclines determinations within a 48.1-4.8 x 10(3) ppm for TCH, 49.1-4.9 x 10(3) ppm for OTCH and 51.5-5.1 x 10(3) ppm for CTCH and a precision better than 0.4% for the three TC species. This procedure accomplishes 150-200 samples h(-1) with a Cu(II) consumption of about 13 mu g determination(-1).

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7