Clavulanate-selective electrodes - application to pharmaceutical formulations

• Type: Article in International Scientific Journal
• Date: 2001

Authors

Pimenta, AM (Author) Other; Couto, CMCM (Author) Other; Araujo, AN (Author) FFUP; Montenegro, MCBSM (Author) FFUP

Journal

Title: Fresenius' Journal of Analytical Chemistry

Vol. 371

Pages: 400-403

ISSN: 0937-0633

Publisher: Springer

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 4 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-000-T46

DOI: 10.1007/s002160100931

Abstract (EN): The construction and assessment of a clavulanate anion-selective electrode and its application to the analysis of pharmaceutical formulations by direct potentiometry are described. The electrode. prepared without inner reference solution, was fabricated by use of a PVC membrane, with bis(triphenyl-phosphoranylidene)ammonium clavulanate as ion-exchanger dissolved in 2-nitrophenyl octyl ether as intermediate solvent and p-t-octylphenol as additive. The response of the electrode was linearly dependent on concentration within the range 2.4 x 10(-3)-1 x 10(-1) mol dm(-3) (ionic strength adjusted to 0.1 mol dm(-3)); the slope of the calibration plot was -59.4 +/-0.9 mV decade(-1) and the reproducibility +/-0.6 mV day(-1). The response time was less than 20 s. Relative errors were <3.5% when results from analysis by direct potentiometry were compared with those from the reference method.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4