New insights into the oxidation pathways of apomorphine

• Type: Article in International Scientific Journal
• Date: 2002

Authors

Garrido, Jorge M P J (Author) Other; Delerue-Matos, C. M Delerue (Author) Other; Borges, Fernanda Fernanda M (Author) FFUP; Macedo, Tice Reis A (Author) Other; Oliveira-Brett, A. M. (Author) Other

Journal

Title: Journal of the Chemical Society, Perkin Transactions 2

Pages: 1713-1717

ISSN: 0300-9580

Publisher: Chemical Society

Indexing

ISI Web of Knowledge - 22 Citations

Scopus - 27 Citations

Other information

Authenticus ID: P-000-RH3

DOI: 10.1039/b204605a

Abstract (EN): A detailed study of the oxidative behaviour of apomorphine in aqueous media is reported. Resorting to the synthesis of apomorphine derivatives it was possible to identify all the anodic oxidation peaks of apomorphine, which are related to the oxidation of the catechol and tertiary amine groups. These findings were revealed to be important since they could lead to a better understanding of the biological interactions of apomorphine and gain insight into its metabolic pathways. During the voltammetric studies, it was also found that apomorphine forms a complex with borate through the catechol group leading to an increase of its oxidation potential. This property could be very useful with regard to the stabilization of apomorphine solutions since it could drastically reduce its autoxidation.

Language: English

Type (Professor's evaluation): Scientific