Nanocarrier-Mediated Topical Insulin Delivery for Wound Healing

• Type: Another Publication in an International Scientific Journal
• Date: 2021

Authors

Macedo, AS (Author) Other; Mendes, F (Author) Other; Filipe, P (Author) Other; Salette Reis (Author) FFUP; Fonte, P (Author) Other

Journal

Title: Materials

Vol. 190

Final page: 4257

ISSN: 1996-1944

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Other information

Authenticus ID: P-00V-7T5

DOI: 10.3390/ma14154257

Abstract (EN): Wound care has been clinically demanding due to inefficacious treatment that represents an economic burden for healthcare systems. In Europe, approximately 7 million people are diagnosed with untreated wounds, leading to a cost between 6.000euro and 10.000euro per patient/year. In the United States of America, 1.5 million people over 65 years old suffer from chronic wounds. A promising therapeutic strategy is the use of exogenous growth factors because they are decreased at the wound site, limiting the recovery of the skin. Insulin is one of the cheapest growth factors in the market able to accelerate the re-epithelialization and stimulate angiogenesis and cell migration. However, the effectiveness of topical insulin in wound healing is hampered by the proteases in the wound bed. The encapsulation into nanoparticles improves its stability in the wound, providing adhesion to the mucosal surface and allowing its sustained release. The aim of this review is to perform a standing point about a promising strategy to treat different types of wounds by the topical delivery of insulin-loaded nanocarriers.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 22