Subpopulations of High-Density Lipoprotein: Friends or Foes in Cardiovascular Disease Risk in Chronic Kidney Disease?

• Type: Another Publication in an International Scientific Journal
• Date: 2021

Authors

Coimbra, S (Author) Other; Reis, F (Author) Other; Valente, MJ (Author) Other; Rocha, S (Author) Other; Cristina Catarino (Author) FFUP; Rocha Pereira, P (Author) Other; Sameiro Faria, M (Author) Other; Bronze da Rocha, E (Author) FFUP; Belo, L (Author) FFUP; Alice Santos Silva (Author) FFUP

Journal

Title: Biomedicines

Vol. 9

Final page: 554

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00T-ZAS

DOI: 10.3390/biomedicines9050554

Abstract (EN): Dyslipidemia is a major traditional risk factor for cardiovascular disease (CVD) in chronic kidney disease (CKD) patients, although the altered lipid profile does not explain the number and severity of CVD events. High-density lipoprotein (HDL) is a heterogeneous (size, composition, and functionality) population of particles with different atherogenic or atheroprotective properties. HDL-cholesterol concentrations per se may not entirely reflect a beneficial or a risk profile for CVD. Large HDL in CKD patients may have a unique proteome and lipid composition, impairing their cholesterol efflux capacity. This lack of HDL functionality may contribute to the paradoxical coexistence of increased large HDL and enhanced risk for CVD events. Moreover, CKD is associated with inflammation, oxidative stress, diabetes, and/or hypertension that are able to interfere with the anti-inflammatory, antioxidative, and antithrombotic properties of HDL subpopulations. How these changes interfere with HDL functions in CKD is still poorly understood. Further studies are warranted to fully clarify if different HDL subpopulations present different functionalities and/or atheroprotective effects. To achieve this goal, the standardization of techniques would be valuable.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14