Congenital posthemorrhagic hydrocephalus: A case of fetomaternal alloimmune thrombocytopenia

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Povoa, AM (Author) Other; ramalho, c (Author) Other; Machado, AP (Author) Other; matias, a (Author) FMUP; Montenegro N (Author) FMUP

Journal

Title: Fetal Diagnosis and Therapy

Vol. 22

Pages: 321-324

ISSN: 1015-3837

Publisher: Karger

Indexing

ISI Web of Knowledge - 6 Citations

Scopus - 6 Citations

Other information

Authenticus ID: P-004-D57

DOI: 10.1159/000103288

Abstract (EN): Fetal/neonatal alloimmune thrombocytopenia (NAIT) results from fetomaternal mismatch for human platelet alloantigens leading to antibody-mediated destruction of fetal platelets. This is one of the most common causes of severe thrombocytopenia in the newborn with an incidence of 1/800-1,000. In the most severe cases, NAIT may result in intracranial hemorrhage and may lead to death or neurologic sequelae. We report a case of fetal hydrocephalus caused by NAIT and discuss the importance of making an accurate prenatal diagnosis to improve the management of the current pregnancy and the outcome of subsequent pregnancies. Screening of female siblings of affected cases is recommended in order to detect at-risk individuals. Copyright (c) 2007 S. Karger AG, Basel.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4