Effect of competitive swimming on airway inflammation: A 3-yr longitudinal study

• Type: Another Publication in an International Scientific Journal
• Date: 2014

Authors

Mariana Couto (Author) Other; Patricia Andrade (Author) Other; Marta Pereira (Author) Other; Joao Araujo (Author) Other; Pedro Moreira (Author) FCNAUP; Luis Delgado (Author) Other; Andre Moreira (Author) Other

Journal

Title: Pediatric Allergy and Immunology

Vol. 25

Pages: 193-195

ISSN: 0905-6157

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 12 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

CORDIS: Health sciences

Other information

Authenticus ID: P-009-H8E

DOI: 10.1111/pai.12198

Abstract (EN): Background Allergy to cats and dogs and polysensitization towards these animals are associated with severe childhood asthma. Molecular-based allergy diagnostics offers new opportunities for improved characterization and has been suggested to be particularly useful in patients with polysensitization and/or severe asthma. The aim was to use extract- and molecular-based allergy diagnostics to compare patterns of IgE sensitization towards aeroallergens in children with problematic severe and controlled asthma. Methods Children with a positive ImmunoCAP towards any furry animal (cat, dog or horse) were recruited from a Nationwide Swedish study on severe childhood asthma. Severe (n=37, age 13years) and controlled (n=28, age 14years) asthmatics underwent assessment of allergic sensitization by ImmunoCap (kU(A)/l) and immunosolid-phase allergen chip (ISAC). In addition, Asthma Control Test, spirometry and a methacholine challenge were performed. Results Children with severe asthma had lower asthma control (p<0.001) and FEV1 (p=0.001) and more bronchial hyper-responsiveness (p=0.008) in spite of high doses of inhaled steroids (>= 800 mu g budesonide). Children with severe asthma displayed higher levels of IgE antibodies towards cat (17 vs. 3.9, p=0.027), dog (3.8 vs. 1.2, p=0.012) and horse (7.4 vs. 0.7, p=0.014). Sensitization towards Can f 2 (22% vs. 0%, p=0.009) and Equ c 1 (51% vs. 25%, p=0.03) was more common in severe asthma. IgE levels towards Equ c 1 correlated with asthma control (r=-0.41, p=0.04). Conclusion Children with severe allergic asthma had higher sIgE levels to cat, dog and horse. Molecular-based allergy diagnostics revealed a more complex molecular spreading of allergen components in children with the most severe disease.

Language: English

Type (Professor's evaluation): Scientific

Notes: letter

No. of pages: 3