Project: 2024.16701.PEX

Project name:	NERO4PDT - ROS-sensitive nanoparticles as carriers for multi-drug delivery: a new road for Parkinson's disease therapy
Project code:	2024.16701.PEX
Proposing institution/Lead promoter/Coordinating entity:	Faculdade de Medicina da Universidade do Porto
Partner(s)/Co-promoter(s)/Participating institution(s):	Universidade de Santiago Compostela; University of Bayreuth
Date of approval:	2025-11-24
Start date:	2026-02-02
Completion date:	2027-08-01

Eligible Cost of the Project

Total Eligible Cost:

59.999,08 EUR

Objectives, activities and expected/achieved results

1) Conjugate the PNAM polymer with DFO;
2) Develop libraries of DF@DL and DF@OR via PISA technique with 10% (w/w free PNAM) of DFO-PNAM and different percentage of APDs initial feeding;
3) Prepare a library of DF@DLOR nanoplatforms composed by DF@DL and DF@OR;
4) Evaluate NPs' physicochemical and morphological features as well as their storage stability;
5) Evaluate the APDs' kinetic release of the most promising PNN NPs under physiological and oxidative conditions;
6) Measure the interaction of the DF@DLOR with nasal mucous;
7) Evaluate the toxicological and pharmacological profile of the DF@DLOR in dopaminergic neuronal (SH-SY5Y), epithelial (RPMI 2650), microgial (HMC3) and hepatic (HepG2) cells;
8) Study the pharmacological performance of DF@DLOR in a human Substantia Nigra Brain-Chip.

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