Biochemistry II

Code:

CN21001

Acronym:

BIOQII

Keywords
Classification	Keyword
OFICIAL	Physical Sciences
OFICIAL	Health Sciences

Instance: 2017/2018 - 1S

Active?	Yes
Web Page:	http://bioquimica.med.up.pt/ensino/index.html
Course/CS Responsible:	Nutrition Sciences

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
CNUP	88	Plano oficial	2	-	5	49	135

Teaching language

Portuguese

Objectives

This course follows a sequence of disciplines that, as a whole, aim to be coherent.
Thus, based on knowledge and training in terms of biochemical thinking acquired in the previous units of Organic Chemistry and Biochemistry I, the intention is to start learning the most important chapters of human metabolism, for the integrated understanding of health status and some diseases, selected by criteria of prevalence and / or exemplary teaching.
It is not intended that students learn to describe by heart the metabolic pathways, but learn to know how to read them as you read a map, seeing as the intermediate metabolites are related to each other, where are the key regulatory points and how the different pathways integrate, where are active enzymes affected by known diseases, or enzymes that are drugs or poisons targets, and also to understand how changes in one system can lead to changes in other systems.
The knowledge that allow us to understand why one diet is better than another, what are the nutritional needs of people in the various stages of development, several instances of health or disease, and also the basis on which to interpret and evaluate data that they acquire about the risks and health benefits of certain dietary changes are mostly in biochemistry.
It is understandable, that contents in this unit are essential knowledge for someone wishing to have a successful and autonomous future with a degree in Nutrition and Food Sciences.

Lipid metabolism will be the main subject of this unit.

Learning outcomes and competences

In this course we intend to continue learning the human metabolism, focusing on lipid metabolism, for an integrated understanding of health status and some diseases, selected by criteria of prevalence and / or exemplary teaching.
At the end of this course the student should be able to:
- List major pathways associated with lipid metabolism
- Understand key points for the regulation and integration of the different metabolic pathways
- Describe relationship between the different intermediate metabolites ,
- Describe action of enzymes involved in known diseases or affected by drugs.

Working method

Presencial

Program

Aspects of carbohydrate metabolism relevant to lipid metabolism
Digestion and absorption of lipids.

Study of lipidic metabolism and their regulation. Namely: synthesis and oxidation of fatty acids, metabolism of ketone bodies, synthesis of phospholipids and glycolipids, structure and metabolism of plasma lipoproteins, metabolism of triacylglycerols, metabolism of cholesterol and bile acids.

Lipid metabolism diseases, namely atherosclerosys, metabolic síndrome and stress

Lipossoluble vitamins and hormones

Integration of carbohydrate and lipidic metabolism.

Mandatory literature

Murray Robert K. 070; Harperc2b4s illustrated biochemistry. ISBN: 978-0-07-179277-6
Baynes, John W. 340; Medical biochemistry. ISBN: 978-0-323-05371-6
Berg Jeremy; Biochemistry. ISBN: 978-1-4292-7635-1
Brody Tom; Nutritional biochemistry. ISBN: 0-12-134836-9
Nelson David L.; Lehninger Principles of Biochemistry. ISBN: 978-0-7167-7108-1
Stipanuk Martha 340; Biochemical, physiological, molecular aspects of human nutrition. ISBN: 978-4-4160-0209-3

Complementary Bibliography

Frayn K.N.; Regulação Metabólica, 2012

Teaching methods and learning activities

The unit program includes 2 lectures of 1 hour each and a small group class (TG) of 1h30 weekly. In this small group classes students will present and discuss topics on lipid metabolism, allowing them to reflect and learn individually and with each other. Beyond theoretical aspects students will be confronted with practical issues and problem resolution related with metabolic pathways and their relation with health and disease.

Students will be assessed in these small group classes between 0-20 values (TG) depending on their participation, knowledge and diligence.

Each week there will be an assessment of the issues addressed (to be held preferably on Fridays) with a maximum of 10 questions. This evaluation will be carried out via Moodle. At the end of the semestre will be made the average of ratings (MA), rejecting the two lowest and the highest scores. Students who have not responded to at least 11 weekly evaluations will be considered as failed.

For students who have made at least 11 weekly evaluations the final grade (NF) is given by:

NF = MA * 0.75 * 0.25 + TG

For students who have not passed or wishing to make improvement note, there will be a written test at "época de recurso" - Written examination (PE) - Consists of a series of multiple choice questions, a small number of open response questions and themes for development..

The final grade (NF) is the weighted average of the written test (75%) and group work (25%).

NF = PE * 0.75 * 0.25 + TG

Evaluation Type

Distributed evaluation without final exam

Assessment Components

Designation	Weight (%)
Participação presencial	25,00
Teste	75,00
Total:	100,00

Eligibility for exams

Students must attend at least 2/3 of small group classes.

Calculation formula of final grade

Students will be assessed in these small group classes between 0-20 values (TG) depending on their participation, knowledge and diligence.

Each week there will be an assessment of the issues addressed (to be held preferably on Fridays) with a maximum of 10 questions. This evaluation will be carried out via Moodle. At the end of the semestre will be made the average of ratings (MA), rejecting the two lowest and the highest scores. Students who have not responded to at least 11 weekly evaluations will be considered as failed.

For students who have made at least 11 weekly evaluations the final grade (NF) is given by:

NF = MA * 0.75 * 0.25 + TG

For students who have not passed or wishing to make improvement note, there will be a written test at "época de recurso" - Written examination (PE) - Consists of a series of multiple choice questions, a small number of open response questions and themes for development..

The final grade (NF) is the weighted average of the written test (75%) and group work (25%).

NF = PE * 0.75 * 0.25 + TG

Classification improvement

Classification improvement can only be made at "época de recurso". Continuous assessment can only be improved by frequency repetition.

Observations

Baynes JW, Dominiczak MH.: Medical Biochemistry. 3rd. Ed. Elsevier Mosby. New York. 2009.
Berg J.M., Tymoczko J.L. and Stryer L.: Biochemistry. 7th. Ed. International Edition. W.H. Freeman and Company. New York. 2012.
Brody T.: Nutritional Biochemistry. 2nd. Ed. Academic Press. San Diego. 1998.
Murray R.K., Granner D.K., Mayes P.A. and Rodwell V.W.: Harper's Illustrated Biochemistry. 29th. Ed.. McGraw-Hill Medical. London. 2012.
Nelson D.L., Cox M.M.: Lehningher Principles of Biochemistry (5th Ed.). W.H. Freeman and Company, New York. 2008.
Stipanuk M.H.: Biochemical, Physiological, Molecular Aspects of Human Nutrition. 3nd. Ed. Saunders  Elsevier. St. Louis. 2012.