Biochemistry III

Code:

CN22001

Acronym:

BIOIII

Keywords
Classification	Keyword
OFICIAL	Health Sciences
OFICIAL	Physical Sciences

Instance: 2014/2015 - 2S

Active?	Yes
Course/CS Responsible:	Nutrition Sciences

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
CNUP	115	Plano oficial	2	-	5	49	135

Teaching language

Portuguese

Objectives

Objectives of the curricular unit:

1. To contribute for the understanding of biology in humans.

2. To contribute for the acquisition of biochemistry language skillls, and to the knowledge of appropriate methods of study in this scientific area.

3. To identify the composition of living organisms, their chemical reactions, and factors affecting these transformations.

4. To study metabolism, particularly of amino acidic metabolism, synthesis and catabolic pathways of amino acid derivatives.

 

Learning outcomes and competences

Learning outcomes of the curricular unit:

Knowledge of human body composition, chemical reactions and chemical changes with special emphasis on protein and amino acid metabolism.

Students should be able to relate changes in protein, amino acid and lipid metabolism in the context of human nutrition.

Working method

Presencial

Program

1. Protein and amino acid metabolism.

 1.1 Protein digestion and absorption in the digestive system.

 1.2 Nonessential amino acid synthesis.

 1.3  Hydrolysis of endogenous proteins.

 1.4 Catabolism of amino acid carbon skeletons.

 1.5 Amino acid-derived nitrogen metabolism.

 1.6 Surfur metabolism

1.7 Amino acid derivatives with biologic relevance; metabolismo of thyroid hormones, iodine, heme, iron and  purine and pirimidine nucleotides.

1.8 Relevant vitamins in aminoacidic metabolism (B6, B12 and folates).

1.9 Hereditary enzyme defects of aminoacid metabolism.

2 Metabolism integration

2.1 Feeding-starvation cycle.

2.2 Different organs and tissues interdependence.

2.3 Physical exercise.

2.4 Pregnancy and newborn. 

2.5 Oxidative metabolism and energy balance.

2.6 Nitrogen metabolism and nitrogen balance

2.7 Metabolic aspects in some of human common diseases: cachecia, cancer and metabolic síndrome.

Mandatory literature

Frayn, Keith N; Regulação Metabólica. Umas perspetiva focada no organismo humano.; , UPEditorial, 2012. ISBN: 978-989-8265-93-7

Complementary Bibliography

Stipanuk, Martha; Caudill, Marie A; Biochemical, physiological, molecular aspects of human nutrition.; 3rd Ed, Elsevier, 2013. ISBN: 978-1-4377-0959-9
Nelson, David L.; Cox, Michel M; Lehninger Principles of Biochemistry, Macmillan, 2013. ISBN: 978-1-4641-0962-1
Murray Robert K., Bender David K, Botham Kathleen M, Kennelly Peter J, Rodwell Victor W, Weil P Anthony; Harper’s illustrated biochemistry, Lange, 2012. ISBN: 978-0-07-179277-6

Teaching methods and learning activities

Teaching methodology:

Lectures: 50-hour per student, during the second semester, with the following pedagogic items:

- 2 theoretical 60 minute lectures per week.

- one  90-minute group session per week.

 

keywords

Physical sciences > Chemistry > Biochemistry > Metabolism
Health sciences > Medical sciences > Medicine > Nutrition related disorders
Physical sciences > Chemistry > Biochemistry
Natural sciences > Biological sciences > Nutritional sciences

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Designation	Weight (%)
Exame	80,00
Participação presencial	20,00
Total:	100,00

Amount of time allocated to each course unit

Designation	Time (hours)
Estudo autónomo	100,00
Frequência das aulas	45,00
Total:	145,00

Eligibility for exams

Mandatory frequency according to FCNAUP first cycle regulations:

75 % of group sessions.

Calculation formula of final grade

Evaluation:

Final Exam (EF) weighted by continuous assessment in group classes (AC). The equation that defines the final grade is as follows: EF * 0.8 + AC * 0.2

Written test with 3 parts:

I) 30 multiple choice questions;

II) short-answer questions (the student must choose to answer 4 questions out of 6 );

III) one full-answer question (the student must choose to answer 1 question out of 3).

Special assessment (TE, DA, ...)

According to FCNAUP's first cycle regulations.

Classification improvement

According to FCNAUP's first cycle regulations.

Observations

Contacts:

Departamento de Bioquímica, Centro de Investigação Médica, FMUP R. Placido Costa

Contacto eletrónico: ruifonte@med.up.pt