Biochemistry III

Code:

CN22001

Acronym:

BIOIII

Keywords
Classification	Keyword
OFICIAL	Health Sciences
OFICIAL	Physical Sciences

Instance: 2013/2014 - 2S

Active?	Yes
Course/CS Responsible:	Nutrition Sciences

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
CNUP	97	Plano oficial	2	-	5	49	135

Teaching language

Portuguese

Objectives

Objectives

1. To contribute for the understanding of biology in humans.

2. To contribute for the acquisition of biochemistry language skillls, and to the knowledge of appropriate methods of study in this scientific area.

3. To identify the composition of living organisms, their chemical reactions, and factors affecting these transformations.

4. To study metabolism, particularly of amino acidic metabolism, synthesis and catabolic pathways of amino acid derivatives.

Learning outcomes and competences

Knowledge of human body composition, chemical reactions and chemical changes with special emphasis on protein and amino acid metabolism.

Students should be able to relate changes in protein, amino acid and lipid metabolism in the context of human nutrition.

Working method

Presencial

Program

I.  Protein and amino acid metabolism.

1.1 Protein digestion and absorption in the digestive system.

1.2 Nonessential amino acid synthesis.

1.3  Hydrolysis of endogenous proteins.

1.4 Catabolism of amino acid carbon skeletons.

1.5 Amino acid-derived nitrogen metabolism.

1.6 Amino acid derivatives with biologic relevance; Heme metabolism. Synthesis and degradation of purine and pirimidine nucleotides.

1.7 Relevant vitamins in aminoacidic metabolism (B6, B12 and folates).

1.8 Hereditary enzyme defects of aminoacid metabolism.

II. Relevance of biochemistry in the udnerstanding, treatment and prevention of human common diseases.

2.1 Stress.

2.2 Cachexia.

2.3 Metabolic changes linked to metabolic syndrome (obesity and type 2 diabetes).

2.4 Cancer.

III. Metabolism integration.

3.1 Feeding-starvation cycle.

3.2 Different organs and tissues interdependence.

3.3 Physical exercise.

3.4 Pregnancy and newborn. 

3.5 Oxidative metabolism and energy balance.

3.6 Nitrogen metabolism and nitrogen balance 

Mandatory literature

Frayn K.N; Regulação Metabólica., U.Porto Editorial, 2012. ISBN: 9789898265937

Complementary Bibliography

Baynes, John W. 340; Medical biochemistry. ISBN: 978-0-323-05371-6
Murray Robert K. 340; Harperc2b4s illustrated biochemistry. ISBN: 978-0-07-162591-3
Nelson David L.; Lehninger Principles of Biochemistry. ISBN: 978-0-7167-7108-1
Quintas Alexandre 340; Bioquímica. ISBN: 978-972-757-431-5
Stipanuk Martha 340; Biochemical, physiological, molecular aspects of human nutrition. ISBN: 978-4-4160-0209-3
Stryer Lubert; Biochemistry. ISBN: 0-7167-8724-5

Teaching methods and learning activities

Teaching methodology

Lectures: 50-hour per student, during the second semester, with the following pedagogic items:

- 2 theoretical 60 minute lectures per week.

- one  90-minute group session per week.

keywords

Physical sciences > Chemistry > Biochemistry > Metabolism
Health sciences > Medical sciences > Medicine > Nutrition related disorders
Physical sciences > Chemistry > Biochemistry
Natural sciences > Biological sciences > Nutritional sciences

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Designation	Weight (%)
Exame	100,00
Participação presencial	0,00
Total:	100,00

Amount of time allocated to each course unit

Designation	Time (hours)
Estudo autónomo	102,00
Frequência das aulas	48,00
Total:	150,00

Eligibility for exams

Mandatory frequency according to FCNAUP first cycle regulations:

75 % of group sessions.

Calculation formula of final grade

Written test with 3 parts:

- multiple choice questions;

- short-answer questions (the student must choose to answer 4 questions out of 6 );

- one full-answer question (the student must choose to answer 1 question out of 3).

The student’s participation in group class is qualitatively evaluated (insufficient, sufficient, good, very good). The evaluation obtained in group class may increase the final classification up to 2 points out of 20, this only occurs if the student has at least 8 out of 20 points in the written exam.

Special assessment (TE, DA, ...)

According to FCNAUP's first cycle regulations.

Classification improvement

According to FCNAUP's first cycle regulations.

Observations

Contacts:

Departamento de Bioquímica, Centro de Investigação Médica, FMUP R. Placido Costa

Contacto eletrónico: ruifonte@med.up.pt