Development of a Coelenterazine Derivative with Enhanced Superoxide Anion-Triggered Chemiluminescence in Aqueous Solution

• Type: Article in International Scientific Journal
• Date: 2022-05-05

Authors

Luís Pinto da Silva (Author) FCUP; José Pedro Silva (Author) Other; Patricia González-Berdullas (Author) FCUP; Joaquim C G E Esteves da Silva (Author) FCUP

Journal

The Journal is awaiting validation by the Administrative Services.

Title: CHEMOSENSORS

Vol. 10

Pages: 174-174

ISSN: 2227-9040

Indexing

ISI Web of Knowledge - 5 Citations

Scopus

Associated Projects

ChemiTumorTher - Quimioluminescência Marinha como uma Terapia Anticancro de Amplo Espectro com uma Selectividade e Actividade Tumoral Melhorada

Other information

Authenticus ID: P-00W-GYS

DOI: 10.3390/chemosensors10050174

Abstract (EN): Superoxide anion is a reactive oxygen species (ROS) of biological interest. More specifically, it plays a role in intra- and intercellular signaling, besides being associated with conditions such as inflammation and cancer. Given this, efforts have been made by the research community to devise new sensing strategies for this ROS species. Among them, the chemiluminescent reaction of marine Coelenterazine has been employed as a sensitive and dynamic probing approach. Nevertheless, chemiluminescent reactions are typically associated with lower emissions in aqueous solutions. Herein, here we report the synthesis of a new Coelenterazine derivative with the potential for superoxide anion sensing. Namely, this novel compound is capable of chemiluminescence in a dose-dependent manner when triggered by this ROS species. More importantly, the light-emission intensities provided by this derivative were relevantly enhanced (intensities 2.13 x 10(1) to 1.11 x 10(4) times higher) in aqueous solutions at different pH conditions when compared to native Coelenterazine. The half-life of the chemiluminescent signal is also greatly increased for the derivative. Thus, a new chemiluminescence molecule with significant potential for superoxide anion sensing was discovered and reported for the first time.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14