From Natural Products to New Synthetic Small Molecules: A Journey through the World of Xanthones

• Type: Another Publication in an International Scientific Journal
• Date: 2021

Authors

Pinto, MMM (Author) Other; Palmeira, A (Author) Other; Carla Fernandes (Author) FFUP; Resende, DISP (Author) Other; Emilia Sousa (Author) FFUP; Honorina Cidade (Author) FFUP; Tiritan M.E. (Author) FFUP; Marta Correia da Silva (Author) FFUP; Cravo, S (Author) Other

Journal

Title: Molecules

Vol. 26 No. 17

Final page: 431

ISSN: 1420-3049

Publisher: MDPI

Indexing

ISI Web of Knowledge - 60 Citations

Scopus - 67 Citations

Other information

Authenticus ID: P-00T-E9S

DOI: 10.3390/molecules26020431

Abstract (EN): This work reviews the contributions of the corresponding author (M.M.M.P.) and her research group to Medicinal Chemistry concerning the isolation from plant and marine sources of xanthone derivatives as well as their synthesis, biological/pharmacological activities, formulation and analytical applications. Although her group activity has been spread over several chemical families with relevance in Medicinal Chemistry, the main focus of the investigation and research has been in the xanthone family. Xanthone derivatives have a variety of activities with great potential for therapeutic applications due to their versatile framework. The group has contributed with several libraries of xanthones derivatives, with a variety of activities such as antitumor, anticoagulant, antiplatelet, anti-inflammatory, antimalarial, antimicrobial, hepatoprotective, antioxidant, and multidrug resistance reversal effects. Besides therapeutic applications, our group has also developed xanthone derivatives with analytical applications as chiral selectors for liquid chromatography and for maritime application as antifouling agents for marine paints. Chemically, it has been challenging to afford green chemistry methods and achieve enantiomeric purity of chiral derivatives. In this review, the structures of the most significant compounds will be presented.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 43