| Summary: |
We will compare the impact of a clinic-based versus home-based exercise training intervention with telemonitoring on clinical, economic and molecular outcomes of patients with HFpEF. To measure efficacy and gauge the clinical meaning of the interventions we will assess established prognostic markers such peak oxygen consumption, NT-pro-BNP, and quality of life. Second, we will estimate the costeffectiveness of home-base intervention by calculating the ratio of the difference of average costs between the interventions and average quality-adjusted life years. Finally, we will compare the interventions on protein aggregates, inflammation and endothelial dysfunction and repair. With this broad approach to this relevant public health problem, we hope to produce high-quality data to inform the decisions of all the stakeholders in
this process and to unravel molecular pathways and biomarkers that provide a wide picture of the mechanisms underlying the clinical effects of exercise in HFpEF. |