Impact of peginterferon alpha-2b and ribavirin treatment on liver tissue in patients with HCV or HCV-HIV co-infection

• Tipo: Artigo em Revista Científica Internacional
• Data: 2007

Autores

Sarmento Castro, R (Autor) Outra; Horta, A (Autor) Outra; Vasconcelos, O (Autor) Outra; Coelho, H (Autor) Outra; Mendez, J (Autor) Outra; Tavares, AP (Autor) Outra; Seabra, J (Autor) Outra; Duarte, M (Autor) Outra; Chaves, L (Autor) Outra; Fortes, O (Autor) Outra; Recalde, C (Autor) Outra; Ventura, A (Autor) Outra; Pires, N (Autor) Outra; Pinho, L (Autor) Outra; Dias, N (Autor) Outra; Carneiro F (Autor) FMUP

Revista

Título: Journal of Infection

Vol. 54

Páginas: 609-616

ISSN: 0163-4453

Editora: Elsevier

Indexação

ISI Web of Knowledge - 8 Citações

Scopus - 8 Citações

Outras Informações

ID Authenticus: P-004-9TF

DOI: 10.1016/j.jinf.2006.11.010

Abstract (EN): Objective: To evaluate the effect of treatment with peginterferon alpha-2b and ribavirin on liver histology in patients with chronic hepatitis C (CHC) with or without HIV infection. Methods: Patients received peginterferon alpha-2b (1.5 mu/kg/week during the first 4 weeks; 1.0 mu/kg/week thereafter) plus ribavirin (800-1200 mg/day, adjusted for weight) for 24 (genotypes 2/3) or 48 weeks (genotypes 1/4). Paired liver biopsy specimens were obtained at baseline and at the end of follow-up. Results: 108 paired biopsy specimens were available: 67 from HCV-monoinfected and 41 from co-infected patients. At the end of follow-up, necroinflammatory activity (NIA) was significantly reduced (P < 0.001), and fibrosis scores improved by >= 1 point (Ishak et al criteria) in 65.7% of HCV-monoinfected patients. In co-infected patients, NIA was significantly reduced (P < 0.001), and fibrosis scores improved by >= 1 point in 42.5% of cases. In both groups, results were better for patients who attained sustained virological response (SVR). HCV RNA was undetectable in the second biopsy specimens of all patients who attained SVR. Conclusion: Liver fibrosis is reduced significantly after a course of therapy in patients with chronic hepatitis C. Reduction of fibrosis is more significant in patients who are monoinfected with HCV and in those who attained SVR.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8