Piezoelectric pumping in flow analysis: Application to the spectrophotometric determination of gabapentin

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Marta F T Ribeiro (Author) Other; Joao L M Santos (Author) FFUP; Jose L F C Lima (Author) FFUP

Journal

Title: Analytica Chimica Acta

Vol. 600 No. 1

Pages: 14-20

ISSN: 0003-2670

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 25 Citations

ISI Web of Science

Scopus - 34 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

CORDIS: Health sciences

Other information

Authenticus ID: P-004-7EB

DOI: 10.1016/j.aca.2006.11.035

Resumo (PT): Solutions propelling devices are fundamental components of a flow-based analytical manifold. In this work different manifold configurations were implemented to evaluate the performance of multiple piezoelectric micro-pumps used as solutions insertion and propulsion devices. The micro-pumps are piezo-actuated micro-diaphragm pumps with passive check valves characterised by a small compact size and low power demands, and are able to produce reproducible flow rates of up to 4 mL min−1. The flow rate is controlled by the frequency of the piezoelectric actuator (up to 20 Hz). As an additional feature, piezoelectric micro-pumps actuation generates a pulsed flowing stream that ensures a faster sample/reagent mixing contributing to improved reaction development. The developed flow approach was assessed in the spectrophotometric determination of gabapentin in pharmaceutical preparations upon reaction with 1,2-naphthoquinone-4-sulfonate in alkaline medium. Distinct flow manifold configurations were designed for achievement of different solutions management. Linear calibrations plots for gabapentin concentrations of up to 150 mg L−1, with relative standard deviations of less than 1.50% (n = 10) and a sample throughput of about 28 determinations per hour, were obtained. <br> <br> Keywords: Piezoelectric micro-pump; Flow analysis; Pulsed flow; Gabapentin; 1,2-Naphthoquinone-4-sulfonate; Multi-pumping <br> <a target="_blank" href="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF4-4MCMWK2-3&_user=2460038&_coverDate=09%2F26%2F2007&_rdoc=7&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235216%232007%23993999998%23669471%23FLA%23display%23Volume)&_cdi=5216&_sort=d&_docanchor=&_ct=38&_acct=C000057398&_version=1&_urlVersion=0&_userid=2460038&md5=d5bb70761c833e0f9e672dd1e5627721"> Texto integral</a> <br> <br>

Abstract (EN): Solutions propelling devices are fundamental components of a flow-based analytical manifold. in this work different manifold configurations were implemented to evaluate the performance of multiple piezoelectric micro-pumps used as solutions insertion and propulsion devices. The micro-pumps are piezo-actuated micro-diaphragm pumps with passive check valves characterised by a small compact size and low power demands, and are able to produce reproducible flow rates of up to 4mL min(-1). The flow rate is controlled by the frequency of the piezoelectric actuator (up to 20Hz). As an additional feature, piezoelectric micro-pumps actuation generates a pulsed flowing stream that ensures a faster sample/reagent mixing contributing to improved reaction development. The developed flow approach was assessed in the spectrophotometric determination of gabapentin in pharmaceutical preparations upon reaction with 1,2-naphthoquinone-4-sulfonate in alkaline medium. Distinct flow manifold configurations were designed for achievement of different solutions management. Linear calibrations plots for gabapentin concentrations of up to 150mgL(-1), with relative standard deviations of less than 1.50% (n = 10) and a sample throughput of about 28 determinations per hour, were obtained.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7