Project: NORTE2030-FEDER-02713500

Project name:	MitOConexão: Investigating the Mitochondrial Nexus in Onco-Cardiology
Project code:	NORTE2030-FEDER-02713500
Main Objective:	Reforçar a investigação, o desenvolvimento tecnológico e a inovação
Proposing institution/Lead promoter/Coordinating entity:	Faculdade de Medicina da Universidade do Porto
Partner(s)/Co-promoter(s)/Participating institution(s):	Faculdade de Belas Artes da Universidade do Porto; Instituto de Ciências Biomédicas de Abel Salazar
Date of approval:	2025-08-18
Start date:	2025-05-01
Completion date:	2028-04-30

Objectives, activities and expected/achieved results

SMART General Objective
Specific: Strengthen scientific and technological capacities in Northern Portugal by investigating mitochondrial dysfunction as a central pathological mechanism in BC and CVD. The project aims to advance precision medicine and translational research, developing novel, low-cost approaches for remote CV monitoring in BC patients.

Measurable: Generate new knowledge, establish clinically actionable biomarkers, and validate targeted strategies that reduce the dual burden of BC and CVD.

Achievable: Leverage robust research infrastructures, cutting-edge molecular profi ling methods, and strong clinical collaborations to ensure effective project execution and real-world applicability.

Relevant: Address critical health challenges in cardio-oncology and personalized medicine.

Time-Bound: Deliver key research outputs, technological platforms, and knowledge-transfer activities within 36 months, reinforcing national and regional innovation priorities and ensuring sustained impact.

Specific Objectives

1. Characterize Mitochondrial Epigenetic Markers in BC Patients With and Without CVDIdentify and quantify mitochondrial epigenetic markers (e.g., 5hmC, HMGB1) in BC tissue and peripheral blood.

2.Investigate Macrophage Profi ling in Immune Modulation, Cardiovascular Remodeling, and Tumor ProgressionExamine the role of tumor-associated macrophages (TAMs), starting with CD163+ subsets, within BC and correlate infiltration profiles with CVD and oncologic outcomes.

3.Analyze Mitochondrial Stress Markers (Parkin, BNIP3, MnSOD) Linked to Cancer-Driven Cardiovascular DysfunctionAssess the expression of key mitochondrial stress markers in BC patients deemed at risk for CV dysfunction.

4.Identify Biomarkers Predictive of Cardiovascular and Cancer Risks Through Remote MonitoringImplement a cost-effective, long-term monitoring strategy using dried blood spots (DBS) and related methodologies

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