Haplotype study of microsatellites flanking the t(15;17) breakpoint in acute promyelocytic leukemia patients from North Portugal

• Type: Article in International Scientific Journal
• Date: 2002

Authors

Martins, S (Author) Other; Trigo, F (Author) Other; Azevedo, L (Author) Other; Silva, MJ (Author) Other; Guimaraes, JE (Author) FMUP; Amorim, A (Author) FCUP

Journal

Title: Leukemia

Vol. 16

Pages: 1353-1357

ISSN: 0887-6924

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 2 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-000-NWP

DOI: 10.1038/sj.leu.2402525

Abstract (EN): A higher frequency of acute promyelocytic leukemia (APL) has been noted in countries of Southern Europe and among 'Latino' patients of the United States with acute myeloid leukemia (AML). In order to discover whether there is any genetic predisposition to the disease, we analyzed microsatellites flanking PML and RARalpha genes in 29 t(15;17) APL patients from North Portugal and compared them with a control group of 123 healthy individuals. Fluorescent PCR products were analyzed using an automated capillary electrophoresis system and allele and haplotype frequencies of the two populations were determined. No significant differences were found, suggesting the same genetic origin of patients and healthy individuals. As suggested by the four microsatellites screened, MSI (microsatellite instability) does not explain the increased incidence of t(l 5;17) APL in this Portuguese population. These results intend to be a new approach to the study of APL, reflecting the particularity of the disease.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5