Receptor-drug association studies in the inhibition of the hematin aggregation process of malaria

• Type: Article in International Scientific Journal
• Date: 2003

Authors

Portela, C (Author) Other; Afonso, CMM (Author) FFUP; Pinto, MMM (Author) FFUP; Ramos, MJ (Author) FCUP

Journal

Title: FEBS Letters

Vol. 547

Pages: 217-222

ISSN: 0014-5793

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 36 Citations

Scopus - 40 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-000-FVV

DOI: 10.1016/s0014-5793(03)00692-6

Abstract (EN): Docking studies were performed to investigate the binding of several antimalarial compounds to the putative drug receptors involved in the hematin aggregation process. These studies reveal a binding profile that correlates with the complementarity of electrostatic potentials between the receptors and the active molecules. These results allow a possible explanation for the same molecular mechanism shown by 4-aminoquinolines, quinine, mefloquine, halofantrine and hydroxylated xanthones. The docking data presented in this work offer an interesting approach to the design of new molecules with potential antimalarial activity.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6