Recycling antimalarial leads for cancer: Antiproliferative properties of N-cinnamoyl chloroquine analogues

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Bianca C Perez (Author) Other; Iva Fernandes (Author) FCUP; Nuno Mateus (Author) FCUP; Catia Teixeira (Author) Other; Paula Gomes (Author) FCUP

Journal

Title: Bioorganic and Medicinal Chemistry Letters

Vol. 23

Pages: 6769-6772

ISSN: 0960-894X

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 12 Citations

Scopus - 12 Citations

Scientific classification

FOS: Medical and Health sciences > Health sciences

Other information

Authenticus ID: P-006-J4T

DOI: 10.1016/j.bmcl.2013.10.025

Abstract (EN): Cinnamic acids and quinolines are known as useful scaffolds in the discovery of antitumor agents. Therefore, N-cinnamoylated analogues of chloroquine, recently reported as potent dual-action antimalarials, were evaluated against three different cancer cell lines: MKN-28, Caco-2, and MCF-7. All compounds display anti-proliferative activity in the micromolar range against the three cell lines tested, and most of them were more active than their parent drug, chloroquine, against all cell lines tested. Hence, N-cinnamoyl-chloroquine analogues are a good start towards development of affordable antitumor leads.

Language: English

Type (Professor's evaluation): Scientific