Respiratory distress syndrome of the preterm neonate - placenta and necropsy as witnesses

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Rocha, G (Author) Other; Rodrigues, M (Author) Other; Guimarães H (Author) FMUP

Journal

Title: Journal of Maternal-Fetal and Neonatal Medicine

Vol. 24

Pages: 148-151

ISSN: 1476-7058

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 11 Citations

Scopus - 13 Citations

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

CORDIS: Health sciences > Medical sciences

Other information

Authenticus ID: P-002-YZP

DOI: 10.3109/14767058.2010.482613

Abstract (EN): Aim. To assess the agreement between clinical diagnosis of hyaline membrane disease (HMD) and lung necropsy pathological findings of deceased neonates. Material and methods. Review of clinical files and necropsy studies of 40 newborn infants <= 37 weeks gestational age. Results. The concordance between clinics and necropsy for the diagnosis of HMD was 43% (n = 17). At the necropsy study of the lungs, 11 cases (28%) of clinically diagnosed HMD were associated to meconium aspiration, pneumonia, or pulmonary hemorrhage; 12 (30%) cases were pneumonia and/or meconium aspiration and pulmonary hemorrhage without hyaline membranes. Of the 17 pneumonias, 15 (88%) were associated to histological chorioamnionitis, RR 3.76 (95%CI: 1.9-4.2) (p < 0.001). Conclusions. The clinical diagnosis of HMD needs a cautious interpretation, as it may be mistaken, or HMD may occur in association with other pathological situations enhancing a more ominous prognosis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4