Push-out testing and histological evaluation of glass reinforced hydroxyapatite composites implanted in the tibia of rabbits

• Type: Article in International Scientific Journal
• Date: 2001

Authors

Lopes, MA (Author) FEUP; Santos, JD (Author) FEUP; Monteiro, FJ (Author) FEUP; Ohtsuki, C (Author) Other; Osaka, A (Author) Other; Kaneko, S (Author) Other; Inoue, H (Author) Other

Journal

Title: Journal of Biomedical Materials Research

Vol. 54 No. 4

Pages: 463-469

ISSN: 0021-9304

Publisher: Heterocorporation

Indexing

ISI Web of Knowledge - 54 Citations

ISI Web of Science

Scopus - 56 Citations

COMPENDEX

Scientific classification

FOS: Engineering and technology > Environmental biotechnology

Other information

Authenticus ID: P-000-W3M

DOI: 10.1002/1097-4636(20010315)54:4<463::aid-jbm10>3.0.co;2-y

Abstract (EN): In vitro and in vivo bioactivity studies were performed to assess the biocompatibility of CaO-P2O5 glass-reinforced hydroxyapatite (GR-HA) composites. The ability to form an apatite layer by soaking in simulated body fluid (SBF) was examined and surfaces were characterized using FTIR reflection and thin-film X-ray diffraction analyses. Qualitative histology, histomorphometric measurements, and push-out testing were performed in a rabbit model for characterizing bone/implant bonding. Under the in vitro conditions using SBF, an apatite layer could not be formed on GR-HA composites within 8 weeks. Results of push-out testing showed bonding between the composites and bone, ranging from 130-145 N after 2 weeks of implantation. After the longest implantation period, 16 weeks, the GR-HA composite prepared with the higher content of CaO-P2O5 glass showed the highest bonding force, 606 +/- 45 N, compared to 459 +/- 30 N for sintered HA. Development of immature bone and modifications in the turnover of a more mature bone on the surface of GR-HA composites were similar to those on sintered HA. (C) 2000 John Wiley & Sons, Inc.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7