Dietary (poly)phenols as modulators of the biophysical properties in endothelial cell membranes: its impact on nitric oxide bioavailability in hypertension

• Type: Another Publication in an International Scientific Journal
• Date: 2024

Authors

Reis, A (Author) Other; Rocha, BS (Author) Other; Laranjinha, J (Author) Other; Victor de Freitas (Author) FCUP

Journal

Title: FEBS Letters

ISSN: 0014-5793

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 1 Citation

Other information

Authenticus ID: P-00Z-XWJ

DOI: 10.1002/1873-3468.14812

Abstract (EN): Hypertension is a major contributor to premature death, owing to the associated increased risk of damage to the heart, brain and kidneys. Although hypertension is manageable by medication and lifestyle changes, the risk increases with age. In an increasingly aged society, the incidence of hypertension is escalating, and is expected to increase the prevalence of (cerebro)vascular events and their associated mortality. Adherence to plant-based diets improves blood pressure and vascular markers in individuals with hypertension. Food flavonoids have an inhibitory effect towards angiotensin-converting enzyme (ACE1) and although this effect is greatly diminished upon metabolization, their microbial metabolites have been found to improve endothelial nitric oxide synthase (eNOS) activity. Considering the transmembrane location of ACE1 and eNOS, the ability of (poly)phenols to interact with membrane lipids modulate the cell membrane's biophysical properties and impact on nitric oxide (center dot NO) synthesis and bioavailability, remain poorly studied. Herein, we provide an overview of the current knowledge on the lipid remodeling of endothelial membranes with age, its impact on the cell membrane's biophysical properties and center dot NO permeability across the endothelial barrier. We also discuss the potential of (poly)phenols and other plant-based compounds as key players in hypertension management, and address the caveats and challenges in adopted methodologies. Age is a risk factor to the onset and progression of hypertension, though adherence to plant-based diets improves blood pressure. Herein, we propose the potential of food (poly)phenols to fluidify cholesterol-rich endothelial membranes and improve the diffusion of nitric oxide (center dot NO) contributing to enhanced bioavailability of vascular center dot NO and the nutritional management of hypertension. image

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 21