Water-Soluble Saccharina latissima Polysaccharides and Relation of Their Structural Characteristics with In Vitro Immunostimulatory and Hypocholesterolemic Activities

• Type: Article in International Scientific Journal
• Date: 2023

Authors

Moreira, ASP (Author) Other; Gaspar, D (Author) Other; Ferreira, SS (Author) Other; Alexandra Correia (Author) ICBAS; Manuel Vilanova (Author) ICBAS; Perrineau, MM (Author) Other; Kerrison, PD (Author) Other; Gachon, CMM (Author) Other; Domingues, MR (Author) Other; Coimbra, MA (Author) Other; Coreta-Gomes, FM (Author) Other; Nunes, C (Author) Other

Journal

Title: Marine Drugs

Vol. 21

Final page: 183

ISSN: 1660-3397

Publisher: MDPI

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 3 Citations

Other information

Authenticus ID: P-00Y-74X

DOI: 10.3390/md21030183

Abstract (EN): Brown macroalgae are an important source of polysaccharides, mainly fucose-containing sulphated polysaccharides (FCSPs), associated with several biological activities. However, the structural diversity and structure-function relationships for their bioactivities are still undisclosed. Thus, the aim of this work was to characterize the chemical structure of water-soluble Saccharina latissima polysaccharides and evaluate their immunostimulatory and hypocholesterolemic activities, helping to pinpoint a structure-activity relationship. Alginate, laminarans (F1, neutral glucose-rich polysaccharides), and two fractions (F2 and F3) of FCSPs (negatively charged) were studied. Whereas F2 is rich in uronic acids (45 mol%) and fucose (29 mol%), F3 is rich in fucose (59 mol%) and galactose (21 mol%). These two fractions of FCSPs showed immunostimulatory activity on B lymphocytes, which could be associated with the presence of sulphate groups. Only F2 exhibited a significant effect in reductions in in vitro cholesterol's bioaccessibility attributed to the sequestration of bile salts. Therefore, S. latissima FCSPs were shown to have potential as immunostimulatory and hypocholesterolemic functional ingredients, where their content in uronic acids and sulphation seem to be relevant for the bioactive and healthy properties.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15