Key production parameters for the development of solid lipid nanoparticles by high shear homogenization

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Souto, EB (Author) Other; Doktorova, S (Author) Other; Zielinska, A (Author) Other; Silva, AM (Author) Other

Journal

Title: Pharmaceutical Development and Technology

Vol. 24

Pages: 1181-1185

ISSN: 1083-7450

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 6 Citations

Scopus - 16 Citations

Other information

Authenticus ID: P-00Q-ZST

DOI: 10.1080/10837450.2019.1647235

Abstract (EN): In this work, we report the development and optimization of solid lipid nanoparticles (SLN) production by a simple, fast, and cost-effective high shear homogenization process. A screening of several solid lipids (Compritol 888 ATO, Precirol ATO 5, Cetyl Palmitate, Dynasan 118, Imwitor 900K, Stearic acid) has been carried out in combination with Poloxamer 188 as the selected surfactant, based on the mean particle size and polydispersity index. The improvement of the physical stability of the SLN dispersions was achieved by the use of a cationic lipid (cetyl trimethylammonium bromide) reaching zeta potential values above +60 mV. Combining the optimized speed and time of shear, monodispersed SLN (PdI < 0.25) under the nanometer range could be produced.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5