In vitro multifunctionality of phlorotannin extracts from edible Fucus species on targets underpinning neurodegeneration

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Barbosa, M (Author) Other; Patricia Valentao (Author) FFUP; Ferreres, F (Author) Other; Gil Izquierdo, A (Author) Other; Paula B Andrade (Author) FFUP

Journal

Title: Food Chemistry

Vol. 333

ISSN: 0308-8146

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 6 Citations

Other information

Authenticus ID: P-00S-EPW

DOI: 10.1016/j.foodchem.2020.127456

Abstract (EN): Bioprospecting for seaweed-derived multimodal acting products have earned increasing attention in the fight against diseases of multifactorial origin, such as neurodegenerative conditions. This is a pioneer study on the in vitro screening of neuroactive properties of phlorotannin-targeted extracts from edible Fucus species. Phlorotannin extracts exhibited multifunctional antioxidant properties, which were suggested to be responsible for counteracting glutamate toxicity in neuronal human-derived SH-SY5Y cells. They also inhibited the activity of enzymes (cholinesterases, monoaminoxidases A and B, and tyrosinase) linked to a set of events that contribute to the onset/progression of neurodegeneration. In general, the bioactivities were correlated with the total phlorotannin content and phloroglucinol tetramers were suggested to be behind the observed effects. The capacity of the phlorotannin extracts to interact with multiple in vitro targets underpinning neurodegeneration points to the potential interest of the selected seaweed species for development of new added-value products and promising neuroactive agents.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10