Nanoemulsions for delivery of flavonoids: formulation and in vitro release of rutin as model drug

• Type: Article in International Scientific Journal
• Date: 2014

Authors

Macedo, AS (Author) Other; Quelhas, S (Author) Other; Silva, AM (Author) Other; Souto, EB (Author) Other

Journal

Title: Pharmaceutical Development and Technology

Vol. 19

Pages: 677-680

ISSN: 1083-7450

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 18 Citations

Scopus - 28 Citations

Other information

Authenticus ID: P-006-HT6

DOI: 10.3109/10837450.2013.823989

Abstract (EN): The aim of the present study is to design and characterize a rutin-loaded nanoemulsion (RT-NE) and determine the release profile of the drug in vitro. RT-NE was prepared by a high pressure homogenization technique. The obtained droplets were analyzed by optical microscopy and were shown to be of spherical shape. By dynamic light scattering, characterization of RT-NE showed an average diameter of 127 nm, polydispersity index of 0.168 and zeta potential values near neutrality (-3.49 mV). Encapsulation efficiency was of similar to 82% (82.3 +/- 1.62%). Drug release was characterized by an initial burst which decreased over the time, showing a sustained release profile. After 24 h, rutin released from NE reached nearly 65%. The developed system proved to be stable and suitable to encapsulating poorly water-soluble drugs.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4